Also offered as gene-to-structure service.
With cutting-edge cryo-electron microscopy and expert data analysis, we deliver reliable,
high-resolution Cryo-EM structures providing essential insights for drug discovery and
protein engineering.
We solve the structure of proteins and complexes to near-atomic resolution (2-3 Å). Cryo-EM is ideal for cases not suitable for X-ray crystallography, be it membrane proteins, flexible antibody-antigen complexes or large, transitional assemblies. Cryo-EM
reveals vital information about conformations, active sites and interfaces like epitopes, invaluable for drug discovery, protein engineering and validation.
Technologically we partner with institutions such as the EMBL HD and the ER-C Jülich to provide cutting edge microscopy data combined with our inhouse specialists for sample preparation and data analysis.
In situ cryo-ET: illuminating the molecular landscape of cells and tissues – where drug discovery meets biological reality.
Cryo-ET allows to directly visualize proteins and complexes inside intact cells and tissues at nanometer resolution. Tilt-series acquisition and 3D reconstruction reveal the spatial organization of macromolecules, giving a true-to-life view of biology under drug treatment or disease conditions. This opens the doors to understanding mechanisms of action in native contexts without overexpression, fixation, or isolation artifacts. In situ cryo-ET enables target validation and off-target effect detection by observing endogenous protein structures and interactions, within cellular architecture.
Cryo-ET unveils how drugs reshape macromolecular machinery – right inside the cell!
With X-ray crystallography, we provides precise, reproducible, and cost-effective structure
determination for drug design and protein engineering.
X-ray crystallography remains a cornerstone method for determining macromolecular structures at atomic resolution. The technique is cost-effective, well established, and compatible with high-throughput crystallization and data collection workflows.
With the added power of anomalous scattering to identify metal sites and enable experimental phasing, X-ray crystallography remains an essential tool for structure-guided drug discovery and protein engineering.
Securing a successful structure determination
We offer production & purification services that ensure protein suitability for crystallization/grid preparation in experimental structure determination projects.
Different cellular expression systems
Optimal purification strategy
Thorough quality evaluation
Boost your research by exploiting the full structural potential!
Research and analysis of existing structures
Assessment of experimental & AI-generated models
Computational analysis of structural models and electron density maps
Interpretation of published structures and related publications in context of your goals
Cryo-ET unveils how drugs reshape macromolecular machinery – right inside the cell!
