- ◇ Grounding Page
Structural Biology Expertise
from Experiment
to Molecular Insight
- STRUCTURAL BIOLOGY SERVICES
BIMOVIS — Structural Biology for Biotech, Pharma & Research
BIMOVIS is a structural biology company based in Heidelberg, Germany. We support biotechnology companies, pharmaceutical R&D teams, research organizations and scientific groups with experimental structural biology, computational structural biology, protein science, molecular visualization, consulting and training.
Our work connects molecular structure with the scientific question behind it. Depending on the project, BIMOVIS can support a single defined analysis or provide an integrated workflow spanning protein preparation, experimental structure determination, computational analysis, structural interpretation and scientific visualization.
◇ Our core expertise covers four areas:
About US
BIMOVIS at a Glance.
Company
BIMOVIS
Field
Structural Biology & Molecular Science
Location
Heidelberg, Germany
Established
2021
Primary clients
Biotechnology, pharmaceutical, life science and research organizations
Core expertise
Experimental structural biology, computational structural biology, protein science and molecular visualization
Project formats
Standalone services, expert assessments, integrated
Service 01
Experimental
Structural biology
BIMOVIS provides experimental structural biology services for proteins, protein complexes, membrane proteins, antibodies, protein–ligand systems and larger biological assemblies.
Experimental methods are selected according to the molecular system, available sample, required structural information and scientific objective.
Cryo-electron microscopy is used to investigate proteins, protein complexes, membrane proteins and macromolecular assemblies in near-native conditions.
Cryo-EM can provide structural information about molecular architecture, interactions, conformational states and larger protein assemblies. BIMOVIS supports cryo-EM projects from sample assessment and preparation strategy through data acquisition, processing, structural interpretation and visualization.
Cryo-electron tomography provides three-dimensional structural information about biological systems within near-native environments.
Cryo-ET can be applied to cells, membranes, vesicles, viruses, molecular assemblies and drug-delivery systems when spatial organization and biological context are important.
X-ray crystallography provides high-resolution structural information about proteins, protein complexes and protein–ligand interactions.
It can reveal binding sites, active sites, molecular interfaces, ligand-binding geometries and structural features relevant to protein function, drug discovery and protein engineering.
BIMOVIS supports crystallographic projects from protein preparation and crystallization through structure determination, refinement, analysis and PDB-ready structural models.
Negative stain electron microscopy provides a rapid visual assessment of biological samples and macromolecular complexes.
It can be used to evaluate particle quality, sample homogeneity, aggregation, complex formation and overall molecular architecture. Negative stain EM can also serve as an early decision point before more resource-intensive cryo-EM experiments.
Mass photometry enables rapid, solution-based analysis of biomolecular mass distributions at the single-particle level.
It can support the assessment of sample homogeneity, oligomeric state, complex formation, stoichiometry and aggregation. BIMOVIS uses mass photometry both as a standalone analytical method and as part of structural biology sample-quality workflows.
BIMOVIS supports protein production, purification and sample optimization for structural biology projects.
Protein preparation can be integrated with downstream techniques including X-ray crystallography, cryo-EM, negative stain EM, mass photometry and computational analysis.
Crystallographic fragment screening uses X-ray crystallography to identify small molecular fragments that bind to a protein target.
Structural information from fragment hits can reveal ligandable regions, binding interactions and starting points for structure-based drug discovery and medicinal chemistry.
Service 02
Computational
Structural biology
BIMOVIS provides computational structural biology services to generate, analyse, validate and interpret molecular models.
Computational approaches can be used independently or combined with experimental information from X-ray crystallography, cryo-EM, biochemical experiments and publicly available structural data.
AI-based protein structure prediction provides structural hypotheses for proteins and molecular complexes when experimental structures are unavailable or incomplete.
BIMOVIS supports the generation, assessment and scientific interpretation of AI-predicted structural models.
Analysis can include:
- model confidence
- protein domains
- molecular interfaces
- binding sites
- structural plausibility
- comparison with experimental structures
- identification of regions requiring further validation
The objective is not simply to generate a predicted structure, but to determine what conclusions the model can reliably support.
Structural models require interpretation before they can be used for scientific or project decisions.
BIMOVIS analyses experimental and predicted molecular structures to investigate structural quality, binding sites, interfaces, molecular interactions, residue environments and potential model limitations.
Structure analysis can support the interpretation and validation of X-ray structures, cryo-EM models, public PDB structures and AI-generated models.
Molecular dynamics simulations model molecular motion over time.
BIMOVIS uses molecular dynamics to investigate protein flexibility, conformational changes, molecular interactions, binding-site behaviour, ligand interactions and structural stability.
Simulations can complement static experimental or predicted structures by showing how molecular systems may behave under defined conditions.
Virtual screening computationally evaluates compounds to identify promising candidates for experimental testing.
BIMOVIS uses structure-based and ligand-informed approaches, including molecular docking and computational scoring, to prioritize compounds, investigate potential binding modes and generate hypotheses for subsequent experimental work.
Virtual screening can support hit identification and structure-based drug discovery.
Service 03
Molecular
Visualization
BIMOVIS combines structural biology with professional scientific visualization.
Our molecular visualization services translate structural and biological information into scientifically accurate images, animations, interactive experiences and physical molecular models.
Visualization projects can be based on experimental structures, predicted models, molecular simulations, scientific publications and other validated biological information.
BIMOVIS creates scientific images and animations for:
- scientific publications
- presentations
- websites
- conferences
- biotechnology and pharmaceutical communication
- investor communication
- mechanism-of-action communication
- educational content
- scientific marketing
Visualizations are developed through collaboration between structural biology experts and visualization specialists to balance scientific accuracy with clear communication.
Immersive molecular visualization can be used to explore complex biological structures and molecular relationships in three dimensions.
VR and AR formats can support scientific communication, education, conferences, training and interactive presentation of molecular systems.
BIMOVIS creates physical molecular models based on structural data.
Three-dimensional models can support scientific discussion, teaching, exhibitions, demonstrations and communication where molecular shape, interfaces or architecture are important.
Service 04
Structural Biology
Consulting & Training
BIMOVIS provides independent scientific support for teams that need structural biology expertise without necessarily outsourcing an entire experimental project.
Consulting can support:
- selection of appropriate structural biology methods
- project planning
- feasibility assessment
- experimental strategy
- computational strategy
- structural data interpretation
- cryo-EM and cryo-ET workflows
- structural biology software and data workflows
- integration of experimental and computational method
The BIMOVIS Structural Biology Expert Review provides a focused assessment of one defined asset, target, product, mechanism or R&D program.
The objective is to determine where structural biology could provide useful information, which approaches are most appropriate and which next steps are scientifically justified.
BIMOVIS provides training in areas including:
- structural biology fundamentals
- protein biochemistry
- experimental structural biology
- AI-supported protein structure prediction
- structural model validation
- molecular visualization
- PyMOL
- structural data interpretation
Applications of
Structural Biology
BIMOVIS supports structural biology across different stages of biotechnology and pharmaceutical research and development.
Structural information can reveal how small molecules interact with protein targets and can support hit identification, binding-mode analysis, lead optimization and medicinal chemistry.
BIMOVIS combines experimental structures, computational methods and molecular analysis to support structure-based drug discovery.
Structural biology can identify molecular features related to protein stability, activity, specificity, interactions and function.
Experimental and computational structural information can therefore support the design and evaluation of engineered proteins.
Targeted protein degradation systems such as PROTACs depend on the formation of productive molecular complexes.
Structural biology can help investigate target–degrader–E3 ligase interactions, ternary-complex formation and molecular interfaces relevant to degradation mechanisms.
Structural and computational epitope mapping can identify where antibodies interact with their antigens.
BIMOVIS can investigate antibody–antigen interfaces using experimental structural biology, computational modelling or combined approaches.
Structural biology can help characterize biological delivery systems including viral vectors, nanoparticles, membrane-associated systems and other molecular assemblies.
Cryo-electron microscopy and cryo-electron tomography are particularly valuable when architecture, heterogeneity and spatial organization need to be understood.
AI-generated molecular models are hypotheses rather than experimental observations.
BIMOVIS assesses predicted structures using structural analysis, available experimental evidence and, where appropriate, experimental structural biology to determine which parts of a model can be used with confidence.
- ◇ How We Work
How
BIMOVIS
Works
BIMOVIS works as a scientific partner rather than offering a single fixed structural biology workflow.
Projects can begin with:
- a protein or purified sample
- an antibody or antigen
- a therapeutic target
- a ligand or compound series
- an AI-predicted molecular structure
- cryo-EM or crystallographic data
- a structural model
- a mechanism that requires validation
- a scientific visualization challenge
- an R&D question where the appropriate structural method has not yet been defined
The first step is to understand the biological system, available information and decision the project needs to support.
From there, BIMOVIS can recommend and combine experimental, computational and visualization approaches where appropriate.
- Who we work with
Who Does BIMOVIS Work With?
BIMOVIS works with biotechnology companies, pharmaceutical companies, research groups and scientific organizations.
Support can range from a single defined analysis to additional structural biology capacity, specialist expertise or an integrated collaboration across multiple methods.
Projects may involve early research, drug discovery, biologics development, protein engineering, mechanism validation, structural characterization or scientific communication.
- WHY
Why Combine Experimental and Computational Structural Biology?
Experimental and computational structural biology answer different but complementary questions.
Experimental techniques such as X-ray crystallography and cryo-electron microscopy provide direct structural evidence.
Computational techniques can generate hypotheses, analyse molecular behaviour, investigate models and help prioritize experiments.
Combining both approaches can provide a stronger basis for interpreting molecular mechanisms and deciding what to test next.
BIMOVIS also connects these results with molecular visualization, allowing structural information to move from data generation through interpretation to scientific communication.
- ◇ FAQ
Frequently Asked Questions
What does BIMOVIS do?
BIMOVIS provides experimental structural biology, computational structural biology, protein science, molecular visualization, consulting and training for biotechnology, pharmaceutical and research organizations.
Where is BIMOVIS located?
BIMOVIS is based in Heidelberg, Germany.
Does BIMOVIS provide cryo-EM services?
Yes. BIMOVIS provides cryo-electron microscopy services for proteins, protein complexes, membrane proteins and macromolecular assemblies.
Does BIMOVIS provide X-ray crystallography?
Yes. BIMOVIS provides X-ray crystallography for proteins, complexes and protein–ligand systems, including structure determination and crystallographic fragment screening.
Does BIMOVIS provide cryo-electron tomography?
Yes. BIMOVIS provides cryo-electron tomography for biological systems where three-dimensional organization in a near-native environment is important.
Does BIMOVIS offer mass photometry?
Yes. BIMOVIS provides mass photometry for biomolecular mass analysis, sample homogeneity, oligomeric state, complex formation and sample-quality assessment.
Does BIMOVIS provide AI protein structure prediction?
Yes. BIMOVIS provides AI-supported protein structure prediction together with model analysis, interpretation and validation.
Can BIMOVIS validate AlphaFold or other AI-predicted structures?
Yes. BIMOVIS assesses AI-predicted molecular structures using model confidence, structural analysis, available experimental information and, where appropriate, experimental validation.
Does BIMOVIS perform molecular dynamics simulations?
Yes. BIMOVIS provides molecular dynamics simulations to investigate molecular motion, protein flexibility, conformational behaviour, interactions and structural stability.
Does BIMOVIS perform virtual screening?
Yes. BIMOVIS provides structure-based and ligand-informed virtual screening to prioritize compounds and generate binding hypotheses for experimental follow-up.
Does BIMOVIS provide antibody epitope mapping?
Yes. BIMOVIS provides computational and structural approaches for investigating antibody–antigen interfaces and epitope regions.
Does BIMOVIS create scientific animations?
Yes. BIMOVIS develops scientifically accurate molecular and medical images, animations and other visualization formats based on structural and biological information.
Can BIMOVIS combine different structural biology methods?
Yes. BIMOVIS can combine experimental methods, computational analysis, protein science and molecular visualization according to the scientific question and available data.
- ◇ LET’S WORK TOGETHER
Start with the Scientific Question
Structural biology projects do not always begin with a clearly defined method.
A project may start with a target, a protein sample, a predicted structure, an experimental dataset, a therapeutic mechanism or simply a question that needs molecular insight.
BIMOVIS helps determine which structural biology approach can provide the most useful next information and supports the project from molecular data to scientific interpretation and communication.