ATOMIC DETAIL VIA
X-ray Crystallography

Atomic detail for proteins, complexes and ligand interactions.

High-resolution structures for defined molecular questions.

X-ray crystallography provides atomic-level structural information for proteins, protein complexes, and protein-ligand interactions. It is particularly valuable when details such as binding geometry, active-site architecture, interface contacts, or the structural basis of specificity and stability matter for the next scientific decision.

At BIMOVIS, our X-ray crystallography services are integrated into a broader structural biology strategy. We evaluate the molecule, the available material, and the project question before defining the most practical path through construct design, protein production, crystallization, data collection and structure interpretation.

Our crystallography services support focused questions in structure-based drug design, protein engineering, antibody characterization, and product development. It can also connect with crystallographic fragment screening, computational structural biology, AI structure prediction, and molecular visualization when an integrated workflow provides more complete structural insights.

Atomic-Level Views of Binding and Molecular Recognition.

X-ray crystallography reveals how proteins are organized at atomic resolution, showing the arrangement of key residues and how ligands, cofactors, antibodies, or interaction partners engage their molecular targets. It is especially valuable when high-resolution structural information is needed to understand local architecture, compare variants, or guide rational molecular design.

For drug discovery and biologics development projects, crystallographic structures provide direct insight into binding modes, structure-activity relationships, specificity, stability, and engineered changes. As with every structural biology approach, the value depends on asking the right question and interpreting the structure in the context of the molecule, assay data, and project goal.

High-resolution protein structures and protein complex structures
Ligand binding modes, active sites and interaction geometries
Structural basis of specificity, stability and protein function
Comparison of variants, mutants or engineered constructs
Structural input for SBDD, fragment screening and lead optimization

How we work.

Scientific scoping & construct strategy

We discuss the target, project question, and available information to define a crystallography strategy that fits the molecule and objective.

Protein production & purification

We prepare or assess protein material with attention to purity, homogeneity, stability, and suitability for crystallization.

Crystallization screening

Initial crystallization screens explore conditions that support crystal formation for the target protein, complex, or protein-ligand system.

Optimization & crystal handling

Promising conditions are refined to improve crystal quality, reproducibility, and diffraction behavior.

Diffraction data collection & processing

Crystals are measured, diffraction data are processed and the structure solution strategy is selected based on the system.

Model building, validation & interpretation

We build, refine and validate the structural model, then interpret the result in relation to the scientific question.

Scientific scoping & construct strategy

We discuss the target, project question and available information to define a crystallography strategy that fits the molecule and objective.

Protein production & purification

We prepare or assess protein material with attention to purity, homogeneity, stability and suitability for crystallization.

Crystallization screening

Initial crystallization screens explore conditions that support crystal formation for the target protein, complex or protein-ligand system.

Optimization & crystal handling

Promising conditions are refined to improve crystal quality, reproducibility and diffraction behavior.

Diffraction data collection & processing

Crystals are measured, diffraction data are processed and the structure solution strategy is selected based on the system.

Model building, validation & interpretation

We build, refine and validate the structural model, then interpret the result in relation to the scientific question.

Where X-Ray Crystallography applies.

X-ray crystallography supports projects where atomic detail can clarify binding, function, specificity or rational design.

Structure-Based Drug Design

Atomic-level insight into binding sites, ligand orientation, and structure-activity relationships for structure-guided discovery.

Protein Engineering

Structural comparison of variants, and engineered proteins to support rational design and optimization.

PROTAC Design

Structural information on target proteins, binding sites, or ternary-complex components relevant to degrader design.

Antibody Epitope Mapping

High-resolution characterization of antibody-antigen interfaces where crystallization of the complex is feasible.

AI Structure Model Validation

Experimental structures to assess, refine, or contextualize AI-generated models at atomic detail.

X-ray questions.

When is X-ray crystallography the right choice for my project?

Choose X-ray crystallography services when atomic-level detail will guide a critical scientific decision—such as defining ligand binding, active-site residues, protein-protein interactions, or engineered variants. X-ray crystallography is also a powerful tool for structure-based drug discovery, protein design, antibody epitope mapping, PROTAC targets, and validating AI-predicted models.

How does BIMOVIS use crystallography in a wider structure plan?

Our protein crystallography services begin with your scientific question and the characteristics of your sample. From construct design and protein preparation through crystallization, X-ray data collection, model building, and structural interpretation, we design a practical workflow tailored to your project. When appropriate, we integrate fragment screening, computational structural biology, AI-based structure prediction, and molecular visualization to strengthen the overall strategy.

What type of insight can I expect from a successful structure?

A successful X-ray crystal structure provides high-resolution insight into protein folds, active-site architecture, ligand and cofactor binding, and protein-ligand complex structures. These data support structure-based drug discovery by informing SAR studies, explaining selectivity and stability, revealing molecular mechanisms, and comparing engineered variants or mutants.

What can X-ray crystallography reveal about protein–ligand interactions?

X-ray crystallography provides atomic-resolution views of protein-ligand complex structures, revealing how small molecules interact with binding pockets, active-site residues, cofactors, and surrounding water networks. These insights support rational lead optimization, explain binding affinity and selectivity, and play a central role in structure-based drug discovery.

What are the main stages of your crystallography workflow?

Our X-ray crystallography workflow includes six stages: (1) scientific scoping and construct design, (2) protein production and quality assessment, (3) crystallization screening, (4) crystal optimization and harvesting, (5) X-ray diffraction data collection and structure solution, and (6) model building, validation, and scientific interpretation aligned with your project objectives.

How do complementary services help an X-ray project?

Successful X-ray crystallography services often depend on complementary capabilities. Protein production ensures high-quality samples for crystallization, X-ray fragment screening identifies early binding events for structure-based drug discovery, while structural analysis, model validation, and computational methods help interpret experimental data and evaluate AI-generated models.

Extend your project.

Protein Production & Purification

Protein expression, purification and quality assessment tailored to downstream crystallography workflows.

Crystallographic Fragment Screening

Fragment-based screening by X-ray crystallography to identify early binding events and guide hit development.

Structure Analysis & Model Validation

Expert analysis, validation and interpretation of experimental structures and AI-generated models.

Go deeper in our Knowledge Hub.

Guides, protocols, and reference materials to support your structural biology projects — free to access.

ATOMIC DETAIL VIA X-ray Crystallography