- ◇ SERVICES · EXPERIMENTAL STRUCTURAL BIOLOGY
EXPERIMENTAL
Structural Biology
From protein sample to structural insight.
We offer the full spectrum of experimental structural biology techniques — from classical X-ray crystallography to in-cell cryo-electron tomography — all in-house, with a single team managing your project from sample delivery to PDB deposition.
- STRUCTURE DETERMINATION · SAMPLE QUALITY · MOLECULAR ANALYSIS
Experimental structural biology methods around the scientific question.
Experimental structural biology provides direct molecular information that can guide research, drug discovery, protein engineering, and product development. Depending on the target and project goal, this may mean atomic detail from X-ray crystallography, near-native structures by cryo-EM, spatial context by cryo-ET, or fast analytical readouts from negative stain EM and mass photometry.
At BIMOVIS, we do not treat these methods as separate technical services. We consider the molecule, the available material, and the scientific question together to define a practical experimental path. Depending on the project, this may include protein production and purification, early sample assessment, structure determination, fragment screening, or a combination of complementary approaches.
Our goal is to generate structural information that is interpretable, useful, and connected to the next decision.
Cryo-Electron Microscopy Services
Structural insight for large and dynamic molecular systems.
Cryo-electron microscopy enables structural analysis of protein complexes, membrane proteins, and macromolecular assemblies in near-native conditions. It is particularly valuable for questions involving conformational states, complex architecture, flexibility, or interactions within larger molecular systems.
At BIMOVIS, cryo-EM can be used as a standalone structural biology approach or as part of an integrated workflow with protein production, negative-stain EM, mass photometry, computational analysis, and molecular visualization.
CRYO-EM · 1.8 – 4.0 Å
Cryo-Electron Tomography Services
Molecular architecture in near-native environments.
Cryo-electron tomography enables three-dimensional imaging of biological structures in vitrified samples, making it especially valuable when spatial context matters. It can be used to study complex systems such as cells, vesicles, membranes, viruses, protein assemblies, and drug delivery systems.
At BIMOVIS, we use cryo-ET to investigate how structures are organized in their native-like environment. The method can address questions around molecular organization, heterogeneity, membrane association, and structural context, and can be combined with cryo-EM, computational structural biology, and molecular visualization to connect structural detail with biological context.
CRYO-ET · 2.0 – 4.0 Å
Negative Stain Electron Microscopy Services
Fast visual assessment of particles, complexes and sample quality.
Negative stain electron microscopy provides an early visual readout of biological samples. It can show whether particles are present, how homogeneous they appear, whether aggregation is an issue, and whether a complex forms under the tested conditions.
At BIMOVIS, negative stain EM is often used as a practical decision point before more demanding workflows such as cryo-EM or cryo-ET. It is also useful for comparing constructs, buffers, preparation conditions, or early sample behavior when fast feedback is needed.
NS · 15 – 30 Å
X-ray Crystallography Services
Atomic detail for proteins, complexes, and ligand interactions.
X-ray crystallography provides high-resolution structural information for proteins, protein complexes, and protein-ligand systems. It can reveal binding geometry, active-site architecture, interface contacts and the structural basis of specificity or stability.
At BIMOVIS, crystallography is used for defined molecular questions where atomic detail can support interpretation, comparison, or rational design. It can also connect directly with crystallographic fragment screening, structure-based drug design, model validation, and molecular visualization.
Crystallographic Fragment Screening Services
Direct structural insight into early fragment binding.
Crystallographic fragment screening uses X-ray crystallography to identify small chemical fragments that bind directly to a target protein. The method shows where a fragment binds and how it interacts with the protein at in atomic detail.
At BIMOVIS, crystallographic screening can support early structure-based drug discovery, hit identification, and lead optimization. The value lies not only in finding fragment hits, but in interpreting whether the observed binding modes are chemically meaningful and useful for the next design step.
SCREEN · HTS
Protein Production & Purification Services
Protein samples prepared with the structural biology question in mind.
Structural biology depends on sample quality. Expression level, purity, homogeneity, stability, and complex formation all influence what can be achieved by crystallography, cryo-EM, mass photometry, or other downstream methods.
At BIMOVIS, protein production and purification are connected to the experimental goal from the beginning. We consider the target, construct design, sample history, and intended structural biology workflow to prepare material that is not only pure, but also suitable for the next step.
MP · NATIVE MASS
Mass Photometry Services
Label-free analysis of molecular mass, oligomeric state and complex formation.
Mass photometry provides a fast, label-free readout of molecular mass distributions in solution. It can show whether a protein is monomeric, forms oligomers, contains aggregates, or assembles into the expected complex.
BIMOVIS offers mass photometry as a standalone analytical service and as part of integrated structural biology workflows. It can support sample quality assessment, complex formation studies, formulation questions, batch comparability, and in-process quality control.
SCREEN · HTS
- ◇ RESOURCES & DOWNLOADS
Go deeper in our Knowledge Hub.
Guides, protocols, and reference materials to support your structural biology projects — free to access.