{"id":366,"date":"2024-12-12T06:08:24","date_gmt":"2024-12-12T06:08:24","guid":{"rendered":"https:\/\/bimovis.com\/?page_id=366"},"modified":"2025-10-24T09:14:04","modified_gmt":"2025-10-24T09:14:04","slug":"applications","status":"publish","type":"page","link":"https:\/\/bimovis.com\/de\/applications\/","title":{"rendered":"Anwendungen"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"366\" class=\"elementor elementor-366\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-590e31c e-flex e-con-boxed e-con e-parent\" data-id=\"590e31c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-27b01e8 elementor-widget elementor-widget-video\" data-id=\"27b01e8\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;video_type&quot;:&quot;hosted&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"e-hosted-video elementor-wrapper elementor-open-inline\">\n\t\t\t\t\t<video class=\"elementor-video\" src=\"https:\/\/bimovis.com\/wp-content\/uploads\/2025\/10\/messefilm_final3.mp4\" controls=\"\" preload=\"metadata\" controlslist=\"nodownload\"><\/video>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-116dc46 e-flex e-con-boxed e-con e-parent\" data-id=\"116dc46\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-50fd59a e-con-full e-flex e-con e-child\" data-id=\"50fd59a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1f6942b elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"1f6942b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Die Bestimmung und Interpretation biologischer Strukturen auf atomarer Ebene ist ein wesentlicher Bestandteil der biopharmazeutischen Industrie und der biowissenschaftlichen Forschung und Entwicklung, mit Anwendungen in:<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2095fef elementor-tablet-align-center elementor-align-center elementor-widget elementor-widget-button\" data-id=\"2095fef\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm elementor-animation-float\" href=\"https:\/\/bimovis.com\/de\/contact\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Kontakt<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-99a7445 e-flex e-con-boxed e-con e-parent\" data-id=\"99a7445\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c76ac54 elementor-widget elementor-widget-n-accordion\" data-id=\"c76ac54\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;default_state&quot;:&quot;all_collapsed&quot;,&quot;max_items_expended&quot;:&quot;multiple&quot;,&quot;n_accordion_animation_duration&quot;:{&quot;unit&quot;:&quot;ms&quot;,&quot;size&quot;:400,&quot;sizes&quot;:[]}}\" data-widget_type=\"nested-accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"e-n-accordion\" aria-label=\"Akkordeon. \u00d6ffnen Sie Links mit Enter oder Space, schlie\u00dfen Sie sie mit Escape und navigieren Sie mit den Pfeiltasten.\">\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-2090\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"1\" tabindex=\"0\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-2090\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Strukturbasierte Wirkstoffentwicklung <\/div><\/span>\n\t\t\t\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2090\" class=\"elementor-element elementor-element-fa80050 e-con-full e-flex e-con e-child\" data-id=\"fa80050\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7ff12fc elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"7ff12fc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tPrecise structural knowledge of a therapeutic target \u2013 drug interaction is crucial for any modern drug discovery and development approach.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2090\" class=\"elementor-element elementor-element-f717f9f e-con-full e-flex e-con e-child\" data-id=\"f717f9f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2090\" class=\"elementor-element elementor-element-4b2fd37 e-con-full e-flex e-con e-child\" data-id=\"4b2fd37\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a7339c2 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"a7339c2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Beschleunigung der Hit-To-Lead (H2L)- und Lead-Optimierungsprozesse (LO) durch strukturbasiertes Design mit hochaufl\u00f6senden Protein-Ligand-Strukturen. Dies reduziert Kosten und Entwicklungszeit bei gleichzeitiger Erh\u00f6hung der Zulassungschancen.<\/li><li>Dar\u00fcber hinaus bieten strukturell aufgekl\u00e4rte Targets M\u00f6glichkeiten zur Identifizierung neuartiger Hits (beispielsweise durch kristallographisches Fragment-Screening) oder zur Validierung von Hits, die durch alternative Methoden entdeckt wurden.<\/li><\/ul><p>Die Ber\u00fccksichtigung verschiedener Ans\u00e4tze zur Strukturbestimmung erm\u00f6glicht es uns, f\u00fcr jedes Zielprotein die beste Methode zu verwenden, von einzelnen kleinen Proteinen bis hin zu komplexen interzellul\u00e4ren Anordnungen.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2090\" class=\"elementor-element elementor-element-7c25bab e-con-full e-flex e-con e-child\" data-id=\"7c25bab\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-94dc24d elementor-widget elementor-widget-image\" data-id=\"94dc24d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1129\" height=\"990\" src=\"https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/Picture10.png\" class=\"attachment-full size-full wp-image-1718\" alt=\"\" srcset=\"https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/Picture10.png 1129w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/Picture10-300x263.png 300w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/Picture10-1024x898.png 1024w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/Picture10-768x673.png 768w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/Picture10-14x12.png 14w\" sizes=\"(max-width: 1129px) 100vw, 1129px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-2091\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"2\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-2091\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Epitop-Mapping von Antik\u00f6rpern <\/div><\/span>\n\t\t\t\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2091\" class=\"elementor-element elementor-element-32df289 e-con-full e-flex e-con e-child\" data-id=\"32df289\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5546beb elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"5546beb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tHochaufl\u00f6sende Antik\u00f6rper-Antigen-Strukturen liefern detaillierte Kenntnisse \u00fcber die Wechselwirkung zwischen einem Antik\u00f6rper und seiner Bindungsstelle auf einem Antigen (Epitop) mit einer Aufl\u00f6sung bis in den atomaren Bereich, was f\u00fcr die Entwicklung von Biologika und diagnostischen Verfahren auf Antik\u00f6rperbasis notwendig ist.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2091\" class=\"elementor-element elementor-element-8b96870 e-con-full e-flex e-con e-child\" data-id=\"8b96870\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2091\" class=\"elementor-element elementor-element-ce6ec54 e-con-full e-flex e-con e-child\" data-id=\"ce6ec54\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c78d4a7 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"c78d4a7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Verst\u00e4ndnis der Wechselwirkung zwischen Antik\u00f6rper und Antigen, um die weitere Entwicklung von Antik\u00f6rpern zu erm\u00f6glichen<\/li><li>Verbesserung sowohl der Affinit\u00e4t als auch der Spezifit\u00e4t des Antik\u00f6rpers, ohne Ressourcen f\u00fcr Trial-and-Error-Ans\u00e4tze zu verschwenden.<\/li><li>\u00dcberpr\u00fcfung der Integrit\u00e4t des Antik\u00f6rper-Antigen-Komplexes<\/li><li>Untersuchung von Proteinen, unabh\u00e4ngig von Markierungsmethoden und Cross-linking Artefakten<\/li><\/ul><h6>\u00a0<\/h6><p><a href=\"https:\/\/bimovis.com\/de\/contact\/\">Mehr erfahren!<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2091\" class=\"elementor-element elementor-element-b282502 e-con-full e-flex e-con e-child\" data-id=\"b282502\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-517c930 elementor-widget elementor-widget-image\" data-id=\"517c930\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1430\" height=\"1080\" src=\"https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB07.png\" class=\"attachment-full size-full wp-image-2245\" alt=\"\" srcset=\"https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB07.png 1430w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB07-300x227.png 300w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB07-1024x773.png 1024w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB07-768x580.png 768w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB07-16x12.png 16w\" sizes=\"(max-width: 1430px) 100vw, 1430px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-2092\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"3\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-2092\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Charakterisierung bispezifischer Antik\u00f6rper <\/div><\/span>\n\t\t\t\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2092\" class=\"elementor-element elementor-element-5c22d1d e-con-full e-flex e-con e-child\" data-id=\"5c22d1d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-10361d8 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"10361d8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tBispezifische Antik\u00f6rper (bsAbs) binden zwei Epitope gleichzeitig und bringen so zwei verschiedene Zellen in Nachbarschaft, um eine Immunreaktion auszul\u00f6sen, wie z. B. <u>zum Beispiel bei Krebs- <\/u><u>Immuntherapeutika<\/u><u>.<\/u> Unsere Services erm\u00f6glichen es, die bsAbs auf verschiedenen Ebenen zu untersuchen:\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2092\" class=\"elementor-element elementor-element-d5dd743 e-con-full e-flex e-con e-child\" data-id=\"d5dd743\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2092\" class=\"elementor-element elementor-element-dda2fce e-con-full e-flex e-con e-child\" data-id=\"dda2fce\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-bbf2f67 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"bbf2f67\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul>\n \t<li>Sicherstellung der bsAb-Stabilit\u00e4t (oft problematisch) mit Massenphotometrie<\/li>\n \t<li>Untersuchung einzelner Fab-Antigen-Wechselwirkungen durch R\u00f6ntgenkristallographie oder Kryo-EM<\/li>\n \t<li>Verbesserung der Affinit\u00e4t und Spezifit\u00e4t der einzelnen Fabs durch strukturbasiertes Engineering<\/li>\n \t<li>Untersuchung des Zellengagements der bsAbs unter nahezu nat\u00fcrlichen Bedingungen mit In-situ-Kryo-Elektronentomographie (Kryo-ET)<\/li>\n<\/ul>\nDie Kombination dieser strukturbiologischen und biophysikalischen Methoden erm\u00f6glicht die pr\u00e4zise Entwicklung hochwirksamer und selektiver Antik\u00f6rper mit voraussichtlich weniger Fehlschl\u00e4gen in klinischen Versuchen.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2092\" class=\"elementor-element elementor-element-e25720e e-con-full e-flex e-con e-child\" data-id=\"e25720e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f061647 elementor-hidden-tablet elementor-hidden-mobile elementor-widget elementor-widget-image\" data-id=\"f061647\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1235\" height=\"935\" src=\"https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB08.png\" class=\"attachment-full size-full wp-image-2253\" alt=\"\" srcset=\"https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB08.png 1235w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB08-300x227.png 300w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB08-1024x775.png 1024w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB08-768x581.png 768w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB08-16x12.png 16w\" sizes=\"(max-width: 1235px) 100vw, 1235px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-edc0111 elementor-hidden-desktop elementor-widget elementor-widget-image\" data-id=\"edc0111\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1235\" height=\"935\" src=\"https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB08.png\" class=\"attachment-full size-full wp-image-2253\" alt=\"\" srcset=\"https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB08.png 1235w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB08-300x227.png 300w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB08-1024x775.png 1024w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB08-768x581.png 768w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB08-16x12.png 16w\" sizes=\"(max-width: 1235px) 100vw, 1235px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-2093\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"4\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-2093\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Strukturbasiertes Protein-Engineering <\/div><\/span>\n\t\t\t\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2093\" class=\"elementor-element elementor-element-8fc1b31 e-con-full e-flex e-con e-child\" data-id=\"8fc1b31\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-65d8eb5 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"65d8eb5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tDie gezielte \u00c4nderung von Proteinen ist seit Jahrzehnten ein Eckpfeiler der biotechnologischen Forschung. Mit den j\u00fcngsten Fortschritten im Bereich der Biologika ist sie auch zu einem wichtigen Schwerpunkt der biopharmazeutischen Industrie geworden. Durch die massive Zunahme des Wissens \u00fcber die Struktur und Funktion von Proteinen, ist es heute einfacher, denn je, neue Proteine mit ma\u00dfgeschneiderten Eigenschaften zu entwickeln.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2093\" class=\"elementor-element elementor-element-4137268 e-con-full e-flex e-con e-child\" data-id=\"4137268\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2093\" class=\"elementor-element elementor-element-5d6029e e-con-full e-flex e-con e-child\" data-id=\"5d6029e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8c4030b elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"8c4030b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u00a0<\/p><ul><li>Die Strukturbestimmung ist ein entscheidender Baustein, der die Analyse von Ausgangsproteinen erm\u00f6glicht. Die Erstellung hochaufgel\u00f6sten Strukturen mittels R\u00f6ntgenkristallographie und Kryo-EM Techniken bilden die Grundlage f\u00fcr ein rationales Design und die \u00dcberpr\u00fcfung der hieraus entwickelten Proteine.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2093\" class=\"elementor-element elementor-element-f0c3784 e-con-full e-flex e-con e-child\" data-id=\"f0c3784\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-91336e7 elementor-widget elementor-widget-image\" data-id=\"91336e7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1920\" height=\"1440\" src=\"https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB09.png\" class=\"attachment-full size-full wp-image-2249\" alt=\"\" srcset=\"https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB09.png 1920w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB09-300x225.png 300w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB09-1024x768.png 1024w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB09-768x576.png 768w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB09-1536x1152.png 1536w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB09-16x12.png 16w\" sizes=\"(max-width: 1920px) 100vw, 1920px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-2094\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"5\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-2094\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Wirt-Pathogen-Wechselwirkungen <\/div><\/span>\n\t\t\t\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2094\" class=\"elementor-element elementor-element-2250bfb e-con-full e-flex e-con e-child\" data-id=\"2250bfb\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-64e9067 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"64e9067\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tZu verstehen, wie ein Krankheitserreger mit einer Zielwirtszelle interagiert und sie beeinflusst, ist der Schl\u00fcssel zur Entwicklung von Gegenma\u00dfnahmen wie Impfstoffen oder Antibiotika. Die Strukturbiologie erm\u00f6glicht Einblicke in die Biologie von Krankheitserregern auf verschiedenen Ebenen:\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2094\" class=\"elementor-element elementor-element-2c172f9 e-con-full e-flex e-con e-child\" data-id=\"2c172f9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2094\" class=\"elementor-element elementor-element-50ede75 e-con-full e-flex e-con e-child\" data-id=\"50ede75\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2b4012b elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"2b4012b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Host protein \u2013 viral protein interactions can be investigated with X-ray crystallography or Cryo-EM<\/li><li>Die Kryo-ET erm\u00f6glicht es uns, die pathogenen Prozesse direkt in den Zellen und Geweben zu sehen, die in dem Moment eingefroren wurden, in dem sie stattfanden.<\/li><\/ul><p class=\"translation-block\"><a href=\"https:\/\/www.frontiersin.org\/journals\/molecular-biosciences\/articles\/10.3389\/fmolb.2023.1296941\/full\" target=\"_blank\" rel=\"noopener\" data-cmp-ab=\"2\"><u>Hier<\/u><\/a> mehr \u00fcber die neuesten Fortschritte in der Wirt-Pathogen-Forschung von Cryo-ET erfahren.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2094\" class=\"elementor-element elementor-element-3c9e962 e-con-full e-flex e-con e-child\" data-id=\"3c9e962\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6565e2b elementor-widget elementor-widget-image\" data-id=\"6565e2b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1430\" height=\"1080\" src=\"https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB10-1.png\" class=\"attachment-full size-full wp-image-2339\" alt=\"\" srcset=\"https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB10-1.png 1430w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB10-1-300x227.png 300w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB10-1-1024x773.png 1024w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB10-1-768x580.png 768w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB10-1-16x12.png 16w\" sizes=\"(max-width: 1430px) 100vw, 1430px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-2095\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"6\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-2095\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Erforschung und Entwicklung von Drug-Delivery-Vektoren <\/div><\/span>\n\t\t\t\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2095\" class=\"elementor-element elementor-element-c1e27b8 e-con-full e-flex e-con e-child\" data-id=\"c1e27b8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-225c86b elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"225c86b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tViele moderne Medikamente verwenden spezielle Tr\u00e4gersysteme, um biologische Barrieren zu umgehen und den gew\u00fcnschten Wirkort zu erreichen. Bekannte Beispiele sind RNA-Impfstoffe, Krebstherapeutika und Gentherapie.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2095\" class=\"elementor-element elementor-element-4d5a332 e-con-full e-flex e-con e-child\" data-id=\"4d5a332\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2095\" class=\"elementor-element elementor-element-7b62782 e-con-full e-flex e-con e-child\" data-id=\"7b62782\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-acdc5ae elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"acdc5ae\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Structural biology approaches grant knowledge of the vector\u2019s loading state, morphology, and distribution, which are all key to successful drug delivery vector development.<\/p><ul><li>EM mit Negativf\u00e4rbung ist eine kosteneffiziente Methode zur Bestimmung der Gr\u00f6\u00dfenverteilung, der Morphologie und des Beladungszustands von gro\u00dfen Nanopartikeln auf Lipid- oder Kapsidbasis<\/li><li>Kryo-ET (Elektronentomographie) bildet den Medikamententr\u00e4ger ab <i>in situ<\/i>, w\u00e4hrend es mit den Zielzellen interagiert. Wie keine andere experimentelle Methode erm\u00f6glicht die Kryo-ET ein Verst\u00e4ndnis nicht nur auf morphologischer Ebene, sondern auch auf funktioneller Ebene im Kontext der nat\u00fcrlichen Umgebung.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2095\" class=\"elementor-element elementor-element-beadbb3 e-con-full e-flex e-con e-child\" data-id=\"beadbb3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3fee5e1 elementor-hidden-tablet elementor-hidden-mobile elementor-widget elementor-widget-image\" data-id=\"3fee5e1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1228\" height=\"916\" src=\"https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB11.png\" class=\"attachment-full size-full wp-image-2284\" alt=\"\" srcset=\"https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB11.png 1228w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB11-300x224.png 300w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB11-1024x764.png 1024w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB11-768x573.png 768w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB11-16x12.png 16w\" sizes=\"(max-width: 1228px) 100vw, 1228px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-997d244 elementor-hidden-desktop elementor-widget elementor-widget-image\" data-id=\"997d244\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1228\" height=\"916\" src=\"https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB11.png\" class=\"attachment-full size-full wp-image-2284\" alt=\"\" srcset=\"https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB11.png 1228w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB11-300x224.png 300w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB11-1024x764.png 1024w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB11-768x573.png 768w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB11-16x12.png 16w\" sizes=\"(max-width: 1228px) 100vw, 1228px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-2096\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"7\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-2096\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Validierung von KI-generierten Proteinmodellen <\/div><\/span>\n\t\t\t\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2096\" class=\"elementor-element elementor-element-0b6f226 e-con-full e-flex e-con e-child\" data-id=\"0b6f226\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-01d547e elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"01d547e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tKI-basierte Tools zur Vorhersage von Proteinstrukturen, wie AlphaFold, sowie Tools f\u00fcr das Proteindesign haben die pharmazeutische Industrie revolutioniert, indem sie eine schnelle und genaue Vorhersage und das Design von Proteinstrukturen erm\u00f6glichen.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2096\" class=\"elementor-element elementor-element-4794419 e-con-full e-flex e-con e-child\" data-id=\"4794419\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2096\" class=\"elementor-element elementor-element-5e71e23 e-con-full e-flex e-con e-child\" data-id=\"5e71e23\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-26360f2 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"26360f2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Vorhersagen bleiben jedoch reine Prognosen, bis sie durch experimentelle Methoden validiert werden. Strukturbiologische Experimente gew\u00e4hrleisten die Genauigkeit und Anwendbarkeit von KI-vorgesagten Proteinen in realen Szenarien, was besonders im Bereich der Biopharmazeutika wichtig ist.<\/p><ul><li>Die Strukturbestimmung durch R\u00f6ntgenkristallographie oder Kryo-EM erm\u00f6glicht die \u00dcberpr\u00fcfung der von der KI vorhergesagten Modelle durch den Vergleich von Berechnungs- und experimentellen Daten, die Ermittlung von Diskrepanzen und die Verfeinerung der Vorhersagen.<\/li><li>Die Integration von KI-Vorhersagen mit der Strukturbiologie beschleunigt die Identifizierung neuer Proteinfunktionen und -interaktionen.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2096\" class=\"elementor-element elementor-element-6747ac5 e-con-full e-flex e-con e-child\" data-id=\"6747ac5\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-90540c6 elementor-hidden-tablet elementor-hidden-mobile elementor-widget elementor-widget-image\" data-id=\"90540c6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1080\" height=\"810\" src=\"https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB12.png\" class=\"attachment-full size-full wp-image-2295\" alt=\"\" srcset=\"https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB12.png 1080w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB12-300x225.png 300w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB12-1024x768.png 1024w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB12-768x576.png 768w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB12-16x12.png 16w\" sizes=\"(max-width: 1080px) 100vw, 1080px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ab48743 elementor-hidden-desktop elementor-widget elementor-widget-image\" data-id=\"ab48743\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1080\" height=\"810\" src=\"https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB12.png\" class=\"attachment-full size-full wp-image-2295\" alt=\"\" srcset=\"https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB12.png 1080w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB12-300x225.png 300w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB12-1024x768.png 1024w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB12-768x576.png 768w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB12-16x12.png 16w\" sizes=\"(max-width: 1080px) 100vw, 1080px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-2097\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"8\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-2097\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> PROTAC Design und Entwicklung <\/div><\/span>\n\t\t\t\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2097\" class=\"elementor-element elementor-element-5c0b578 e-con-full e-flex e-con e-child\" data-id=\"5c0b578\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ca611b9 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"ca611b9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tPROTACs (PROteolysis-TArgeting Chimeras) and Molecular Glues \u2013 emerging tools for targeted protein degradation \u2013 are currently redefining our attitude towards small molecule drug development.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2097\" class=\"elementor-element elementor-element-1bf3ff2 e-con-full e-flex e-con e-child\" data-id=\"1bf3ff2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2097\" class=\"elementor-element elementor-element-7d28877 e-con-full e-flex e-con e-child\" data-id=\"7d28877\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3c19f65 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"3c19f65\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Die Strukturbiologie bietet hochaufl\u00f6sende Einblicke in Protein-Protein-Wechselwirkungen, Ligandenbindung und den Aufbau von Komplexen und erm\u00f6glicht so den rationalen Entwurf dieser Molek\u00fcle.<\/p><p>R\u00f6ntgenkristallographie und Kryo-EM helfen dabei, die tern\u00e4ren Komplexe sichtbar zu machen, die sich zwischen dem Zielprotein, der E3-Ubiquitin-Ligase und dem PROTAC-Molek\u00fcl bilden. Auf diese Weise k\u00f6nnen Forschende die L\u00e4nge und Ausrichtung des Linkers f\u00fcr eine effiziente Ubiquitinierung und den anschlie\u00dfenden Abbau optimieren.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2097\" class=\"elementor-element elementor-element-cfc9aab e-con-full e-flex e-con e-child\" data-id=\"cfc9aab\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c1d5d10 elementor-widget elementor-widget-image\" data-id=\"c1d5d10\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1095\" height=\"826\" src=\"https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB13.png\" class=\"attachment-full size-full wp-image-2318\" alt=\"\" srcset=\"https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB13.png 1095w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB13-300x226.png 300w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB13-1024x772.png 1024w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB13-768x579.png 768w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB13-16x12.png 16w\" sizes=\"(max-width: 1095px) 100vw, 1095px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-2098\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"9\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-2098\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Qualit\u00e4tskontrolle <\/div><\/span>\n\t\t\t\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2098\" class=\"elementor-element elementor-element-a33d8c5 e-con-full e-flex e-con e-child\" data-id=\"a33d8c5\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-df2a5ae elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"df2a5ae\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tStable, reproducible, and homogeneous samples are the cornerstone of every biochemical production from enzymes, through antibodies and antigens, to lipid nanoparticles and viral particles.\n\nOur\u00a0 versatile approaches utilize Structural Biology and Biophysics methods to ensure that highest quality samples are used in your studies and development pipelines.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2098\" class=\"elementor-element elementor-element-f4d6f7d e-con-full e-flex e-con e-child\" data-id=\"f4d6f7d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2098\" class=\"elementor-element elementor-element-8f68081 e-con-full e-flex e-con e-child\" data-id=\"8f68081\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ed54302 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"ed54302\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Die Massenphotometrie ist eine schnelle und kosteng\u00fcnstige Methode, mit der Homogenit\u00e4t, Multimerisierungsgrad und zeitliche Stabilit\u00e4t von Proben wie Membranproteinen, Antik\u00f6rpern und ADCs oder AAVs direkt analysiert werden k\u00f6nnen.<\/li><li>R\u00f6ntgenkristallographie und Einzelteilchen-Kryo-EM beweisen wie keine andere Methode die Identit\u00e4t und Qualit\u00e4t der Probe durch direkte Visualisierung<\/li><li>EM mit Negativf\u00e4rbung bietet eine schnelle und bequeme M\u00f6glichkeit zur Analyse gr\u00f6\u00dferer Proben im Hinblick auf Gr\u00f6\u00dfe und Verteilung, insbesondere f\u00fcr die Charakterisierung von AAV und Nanopartikeln<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-2098\" class=\"elementor-element elementor-element-0529fb8 e-con-full e-flex e-con e-child\" data-id=\"0529fb8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8c004ac elementor-hidden-tablet elementor-hidden-mobile elementor-widget elementor-widget-image\" data-id=\"8c004ac\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"851\" height=\"636\" src=\"https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB14.png\" class=\"attachment-full size-full wp-image-2328\" alt=\"\" srcset=\"https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB14.png 851w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB14-300x224.png 300w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB14-768x574.png 768w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB14-16x12.png 16w\" sizes=\"(max-width: 851px) 100vw, 851px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-12c12d3 elementor-hidden-desktop elementor-widget elementor-widget-image\" data-id=\"12c12d3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"851\" height=\"636\" src=\"https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB14.png\" class=\"attachment-full size-full wp-image-2328\" alt=\"\" srcset=\"https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB14.png 851w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB14-300x224.png 300w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB14-768x574.png 768w, https:\/\/bimovis.com\/wp-content\/uploads\/2025\/01\/AB14-16x12.png 16w\" sizes=\"(max-width: 851px) 100vw, 851px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-70d639f e-flex e-con-boxed e-con e-parent\" data-id=\"70d639f\" data-element_type=\"container\" 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and development approach. It facilitates Hit-To-Lead (H2L) [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"content-type":"","footnotes":""},"class_list":["post-366","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Applications - BIMOVIS<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/bimovis.com\/de\/applications\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Applications - BIMOVIS\" \/>\n<meta property=\"og:description\" content=\"https:\/\/bimovis.com\/wp-content\/uploads\/2025\/10\/messefilm_final3.mp4 The determination and interpretation of biological structures at the atomic level is an essential part of biopharmaceutical industry and life science R&amp;D, with applications in: Contact Us Structure-based drug design Precise structural knowledge of a therapeutic target \u2013 drug interaction is crucial for any modern drug discovery and development approach. 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