- ◇ APPLICATIONS · DRUG DELIVERY VECTOR CHARACTERIZATION
DRUG DELIVERY
Vector Characterization
Structural insight into viral particles, delivery systems and formulation-related molecular assemblies.
Particle morphology
Structural heterogeneity
Vector architecture
Formulation context
Drug delivery vectors often depend on more than composition alone. Their function is shaped by particle architecture, morphology, size distribution, assembly state and how structural features change across preparation, formulation or storage conditions.
Structural biology helps make these properties visible. For viral particles, vesicles, protein assemblies or other delivery-related systems, imaging and biophysical analysis can reveal whether the expected structures are present, how homogeneous the sample is and where particle-to-particle differences may influence interpretation.
At BIMOVIS, we support drug delivery vector characterization by connecting structural biology, particle analysis and molecular visualization. Depending on the system and project question, this may involve cryo-EM, cryo-ET, negative stain electron microscopy, mass photometry, image analysis or visual communication of complex particle data.
The goal is to make structural information useful for development decisions: what the particles look like, how consistent they are, which features matter and which questions need further analytical or structural follow-up.
- ◇ WHERE STRUCTURAL BIOLOGY SUPPORTS DRUG DELIVERY VECTOR CHARACTERIZATION
Where structural biology supports drug delivery vector characterization.
VIRAL PARTICLE CHARACTERIZATION
Viral particle characterization
Structural imaging can help assess viral particles and viral vector preparations by showing morphology, integrity, particle distribution and structural heterogeneity. This provides useful context when particle quality or assembly state is central to the project.
MORPHOLOGY & INTEGRITY
Particle morphology and integrity
Negative stain EM, cryo-EM and cryo-ET can reveal whether particles are intact, disrupted, aggregated or present in multiple forms. This helps connect visual particle features with sample preparation, formulation or process-related questions.
STRUCTURAL HETEROGENEITY
Structural heterogeneity
Drug delivery systems are often not uniform. Structural biology can help identify differences between individual particles, vesicles or assemblies and provide a clearer view of how heterogeneous the sample really is.
VECTOR ARCHITECTURE
Vector architecture and organization
Cryo-ET and related imaging approaches can support questions around particle architecture, internal organization, membrane association or spatial arrangement of components. This is especially valuable when the delivery system is too complex to be understood from bulk measurements alone.
FORMULATION & COMPARABILITY
Formulation and comparability context
Structural and biophysical readouts can support comparison of batches, conditions or preparation strategies. They can provide context for in-process quality control, formulation assessment or troubleshooting when particle behavior changes during development.
- ◇ LET’S WORK TOGETHER
Let’s work together
Start with your structural question.
Bring us your viral particles, delivery vector, vesicle system, formulation sample, imaging dataset or particle-related development question. We help identify which structural biology approach is most useful for the next decision.
- ◇ COMPLEMENTARY SERVICES
Extend your project.
Cryo-Electron Tomography
Analyze particle architecture, spatial organization and structural heterogeneity in vitrified delivery systems or complex biological samples.
Negative Stain Electron Microscopy
Get fast visual feedback on particle morphology, aggregation, integrity and sample suitability before deeper structural analysis.
- ◇ RESOURCES & DOWNLOADS
Go deeper in our Knowledge Hub.
Guides, protocols, and reference materials to support your structural biology projects — free to access.