ANTIBODY EPITOPE
Mapping & Biologics

Structural insight into antibody-antigen recognition, biologics function and ADC target engagement.

Epitope mapping

Antibody-antigen complexes

Bispecific antibodies

ADC target engagement

From molecular recognition to biologics decisions.

Antibodies and biologics depend on precise molecular recognition. Structural biology helps show where an antibody binds, how the antigen is presented and which molecular contacts shape specificity, cross-reactivity and functional activity.

This insight is valuable across antibody discovery, candidate comparison and biologics development. It can clarify epitope and paratope interactions, explain differences between candidates, support bispecific antibody design questions and provide structural context for ADC target engagement.

At BIMOVIS, we approach antibody and biologics projects through the question behind the program. Some projects need high-resolution antibody-antigen structures. Others benefit from cryo-EM, X-ray crystallography, AI-supported model analysis, structure comparison, mass photometry or molecular visualization.

The goal is to make molecular recognition easier to interpret: where the biologic engages, which structural features matter and how this insight supports the next scientific, technical or communication step.

Where structural biology supports antibody and biologics projects.

Epitope & paratope understanding

Epitope and paratope understanding

Structural biology helps define where an antibody binds and how the antigen is recognized. It can reveal the molecular contacts that shape the epitope-paratope interaction and support interpretation of binding specificity.

COMPLEX CHARACTERISATION

Antibody-antigen complex characterisation

Cryo-EM, X-ray crystallography and structure analysis can provide molecular insight into antibody-antigen complexes. This helps clarify binding orientation, interface geometry and how the complex relates to the intended biological function.

SPECIFICITY & CROSS-REACTIVITY

Specificity and cross-reactivity

Structural comparison can help explain why an antibody recognizes one target, variant or antigen state over another. It can also highlight regions where cross-reactivity, loss of binding or altered recognition may need closer attention.

BISPECIFIC ARCHITECTURE

Linker geometry and exit vectors

Bispecific antibodies introduce additional structural questions around geometry, spacing, simultaneous engagement and functional complex formation. Structural analysis can help assess whether the intended binding arrangement is plausible and how the molecule presents its binding domains.

ADC TARGET ENGAGEMENT

Molecular glue mechanisms

For antibody-drug conjugates, structural insight can support antigen and epitope understanding, target accessibility, binding orientation and mechanism-of-action communication. This helps connect the antibody component of an ADC to the biological context it needs to address.

HOST-PATHOGEN INTERACTIONS

Host-pathogen interaction studies

Many host-pathogen questions depend on molecular recognition at the interface between pathogen-derived proteins and host factors. Structural biology can help interpret neutralizing epitopes, receptor engagement and interaction surfaces relevant to infectious disease research.

Let’s work together

Start with your structural question.

Bring us your antigen, antibody, biologics candidate, predicted model, structural data, bispecific format or ADC-related target engagement question. We help identify which structural biology approach is most useful for the next decision.

Extend your project.

Cryo-Electron Microscopy

Analyse larger antibody-antigen complexes, biologics and molecular assemblies where near-native structural insight is important.

X-ray Crystallography

Resolve antibody-antigen interfaces at high resolution where crystallization of the complex is feasible.

Molecular Visualization

Create scientific images and animations to communicate epitopes, biologics function, target engagement and mechanism-of-action concepts clearly.

Go deeper in our Knowledge Hub.

Guides, protocols, and reference materials to support your structural biology projects — free to access.

ANTIBODY EPITOPE Mapping & Biologics